Assay Detail
Binding
CHEMBL840054
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Displacement of [125I]AB-MECA binding to Adenosine A3 receptor expressed in CHO cells
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of novel N6-[4-(substituted)sulfonamidophenylcarbamoyl]adenosine-5'-uronamides as A3 adenosine receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 7.84 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431733 | NAMODENOSON | 3.0 | 1 | 9.48 |
| CHEMBL119709 | IB-MECA | — | 1 | 8.96 |
| CHEMBL608755 | — | — | 1 | 8.10 |
| CHEMBL611091 | — | — | 1 | 8.05 |
| CHEMBL611104 | — | — | 1 | 8.00 |
| CHEMBL611095 | — | — | 1 | 8.00 |
| CHEMBL610845 | — | — | 1 | 7.92 |
| CHEMBL610849 | — | — | 1 | 7.85 |
| CHEMBL265587 | — | — | 1 | 7.83 |
| CHEMBL610814 | — | — | 1 | 7.77 |
| CHEMBL610846 | — | — | 1 | 7.72 |
| CHEMBL611089 | — | — | 1 | 7.70 |
| CHEMBL610589 | — | — | 1 | 7.70 |
| CHEMBL610847 | — | — | 1 | 7.66 |
| CHEMBL611090 | — | — | 1 | 7.64 |
| CHEMBL610830 | — | — | 1 | 7.64 |
| CHEMBL610584 | — | — | 1 | 7.64 |
| CHEMBL610837 | — | — | 1 | 7.64 |
| CHEMBL610579 | — | — | 1 | 7.62 |
| CHEMBL611092 | — | — | 1 | 7.62 |
| CHEMBL611099 | — | — | 1 | 7.60 |
| CHEMBL610829 | — | — | 1 | 7.46 |
| CHEMBL464859 | NECA | — | 1 | 7.46 |
| CHEMBL610580 | — | — | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431733 | NAMODENOSON | Ki | = | 0.33 | nM | 9.48 |
| CHEMBL119709 | IB-MECA | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL608755 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL611091 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL611104 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL611095 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL610845 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL610849 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL265587 | — | Ki | = | 14.8 | nM | 7.83 |
| CHEMBL610814 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL610846 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL611089 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL610589 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL610847 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL611090 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL610830 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL610584 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL610837 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL610579 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL611092 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL611099 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL610829 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL464859 | NECA | Ki | = | 34.8 | nM | 7.46 |
| CHEMBL610580 | — | Ki | = | 80.0 | nM | 7.10 |