Assay Detail
Binding
CHEMBL840056
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]MRE3008-F20 binding to human adenosine A3 receptor expressed in CHO cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
New pyrrolo[2,1-f]purine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives as potent and selective human A3 adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.38 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189904 | — | — | 1 | 8.10 |
| CHEMBL193130 | — | — | 1 | 7.10 |
| CHEMBL435887 | — | — | 1 | 6.94 |
| CHEMBL190472 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189904 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL193130 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL435887 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL190472 | — | Ki | > | 1000.0 | nM | - |