Assay Detail
Binding
CHEMBL840078
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Binding affinity for the recombinant XIAP BIR3 protein in displacing a fluorescently labeled Smac peptide
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-based design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 5.64 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL534477 | — | — | 1 | 6.54 |
| CHEMBL535596 | — | — | 1 | 6.46 |
| CHEMBL365059 | — | — | 1 | 6.24 |
| CHEMBL534922 | — | — | 1 | 5.85 |
| CHEMBL556818 | — | — | 1 | 5.63 |
| CHEMBL536268 | — | — | 1 | 5.35 |
| CHEMBL536038 | — | — | 1 | 4.65 |
| CHEMBL557362 | — | — | 1 | 4.37 |
| CHEMBL558170 | — | — | 1 | - |
| CHEMBL537185 | — | — | 1 | - |
| CHEMBL538075 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL534477 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL535596 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL365059 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL534922 | — | Ki | = | 1410.0 | nM | 5.85 |
| CHEMBL556818 | — | Ki | = | 2330.0 | nM | 5.63 |
| CHEMBL536268 | — | Ki | = | 4470.0 | nM | 5.35 |
| CHEMBL536038 | — | Ki | = | 22400.0 | nM | 4.65 |
| CHEMBL557362 | — | Ki | = | 43110.0 | nM | 4.37 |
| CHEMBL558170 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL537185 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL538075 | — | Ki | > | 100000.0 | nM | - |