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Assay Detail

CHEMBL840097

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Binding
Binding affinity for human 5-hydroxytryptamine 6 receptor
ChEMBL ↗
46
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

5-hydroxytryptamine receptor 6 (CHEMBL3371) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

A three-dimensional pharmacophore model for 5-hydroxytryptamine6 (5-HT6) receptor antagonists.
López-Rodríguez ML, Benhamú B, de la Fuente T, Sanz A, Pardo L, Campillo M.
J Med Chem (2005) 48 : 4216 -4219
PubMed 15974573 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 46 8.14 9.90

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL363792 — — 1 9.90
CHEMBL365569 — — 1 9.90
CHEMBL373322 — — 1 9.70
CHEMBL372879 — — 1 9.70
CHEMBL414628 — — 2 9.50
CHEMBL299822 — — 1 9.10
CHEMBL282971 — — 1 9.10
CHEMBL29433 — — 1 9.10
CHEMBL433946 — — 1 9.10
CHEMBL427155 — — 1 9.10
CHEMBL372006 — — 1 9.00
CHEMBL431298 — — 1 9.00
CHEMBL188600 — — 1 8.90
CHEMBL416638 — — 1 8.90
CHEMBL175940 — — 1 8.70
CHEMBL97158 — — 1 8.70
CHEMBL60264 — — 1 8.60
CHEMBL76237 — — 1 8.60
CHEMBL364039 — — 1 8.50
CHEMBL329383 — — 1 8.50
CHEMBL93868 — — 1 8.50
CHEMBL355905 — — 1 8.40
CHEMBL191385 — — 1 8.30
CHEMBL370672 — — 1 8.20
CHEMBL127411 — — 1 8.10
CHEMBL328816 — — 1 7.90
CHEMBL46071 — — 1 7.80
CHEMBL191121 — — 1 7.70
CHEMBL316881 — — 1 7.60
CHEMBL365471 — — 1 7.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL365569 — Ki = 0.1259 nM 9.90
CHEMBL363792 — Ki = 0.1259 nM 9.90
CHEMBL373322 — Ki = 0.1995 nM 9.70
CHEMBL372879 — Ki = 0.1995 nM 9.70
CHEMBL414628 — Ki = 0.3162 nM 9.50
CHEMBL414628 — Ki = 0.3162 nM 9.50
CHEMBL282971 — Ki = 0.7943 nM 9.10
CHEMBL29433 — Ki = 0.7943 nM 9.10
CHEMBL433946 — Ki = 0.7943 nM 9.10
CHEMBL299822 — Ki = 0.7943 nM 9.10
CHEMBL427155 — Ki = 0.7943 nM 9.10
CHEMBL372006 — Ki = 1.0 nM 9.00
CHEMBL431298 — Ki = 1.0 nM 9.00
CHEMBL416638 — Ki = 1.259 nM 8.90
CHEMBL188600 — Ki = 1.259 nM 8.90
CHEMBL97158 — Ki = 1.995 nM 8.70
CHEMBL175940 — Ki = 1.995 nM 8.70
CHEMBL76237 — Ki = 2.512 nM 8.60
CHEMBL60264 — Ki = 2.512 nM 8.60
CHEMBL93868 — Ki = 3.162 nM 8.50
CHEMBL364039 — Ki = 3.162 nM 8.50
CHEMBL329383 — Ki = 3.162 nM 8.50
CHEMBL355905 — Ki = 3.981 nM 8.40
CHEMBL191385 — Ki = 5.012 nM 8.30
CHEMBL370672 — Ki = 6.31 nM 8.20
CHEMBL127411 — Ki = 7.943 nM 8.10
CHEMBL328816 — Ki = 12.59 nM 7.90
CHEMBL46071 — Ki = 15.85 nM 7.80
CHEMBL191121 — Ki = 19.95 nM 7.70
CHEMBL316881 — Ki = 25.12 nM 7.60
CHEMBL365471 — Ki = 31.62 nM 7.50
CHEMBL191415 — Ki = 39.81 nM 7.40
CHEMBL7318 — Ki = 50.12 nM 7.30
CHEMBL367832 — Ki = 50.12 nM 7.30
CHEMBL97492 — Ki = 50.12 nM 7.30
CHEMBL433461 — Ki = 50.12 nM 7.30
CHEMBL415464 — Ki = 50.12 nM 7.30
CHEMBL190521 — Ki = 63.1 nM 7.20
CHEMBL190594 — Ki = 63.1 nM 7.20
CHEMBL191027 — Ki = 79.43 nM 7.10
CHEMBL302845 — Ki = 79.43 nM 7.10
CHEMBL192435 — Ki = 251.19 nM 6.60
CHEMBL362984 — Ki = 630.96 nM 6.20
CHEMBL407860 — Ki = 1000.0 nM 6.00
CHEMBL97819 — Ki = 1000.0 nM 6.00
CHEMBL190468 — Ki = 1258.93 nM 5.90