Assay Detail
Binding
CHEMBL840102
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration against human PPARgamma expressed in HepG2 cells
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis, biological evaluation, and molecular modeling investigation of new chiral fibrates with PPARalpha and PPARgamma agonist activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 5.46 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | 7.41 |
| CHEMBL191275 | — | — | 1 | 6.30 |
| CHEMBL192518 | — | — | 1 | 6.05 |
| CHEMBL426632 | — | — | 1 | 5.82 |
| CHEMBL189116 | — | — | 1 | 5.80 |
| CHEMBL364748 | — | — | 1 | 5.57 |
| CHEMBL191060 | — | — | 1 | 5.44 |
| CHEMBL360420 | — | — | 1 | 5.27 |
| CHEMBL366157 | — | — | 1 | 5.14 |
| CHEMBL369890 | — | — | 1 | 5.05 |
| CHEMBL190905 | — | — | 1 | 4.98 |
| CHEMBL190368 | — | — | 1 | 4.91 |
| CHEMBL364254 | — | — | 1 | 4.90 |
| CHEMBL371320 | — | — | 1 | 4.70 |
| CHEMBL370054 | — | — | 1 | 4.59 |
| CHEMBL683 | CLOFIBRIC ACID | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL121 | ROSIGLITAZONE | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL191275 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL192518 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL426632 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL189116 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL364748 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL191060 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL360420 | — | EC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL366157 | — | EC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL369890 | — | EC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL190905 | — | EC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL190368 | — | EC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL364254 | — | EC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL371320 | — | EC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL370054 | — | EC50 | = | 25700.0 | nM | 4.59 |
| CHEMBL683 | CLOFIBRIC ACID | EC50 | = | 309000.0 | nM | - |