Assay Detail
Binding
CHEMBL840150
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Inhibitory potency against human cloned Carbonic anhydrase II expressed in Escherichia coli strain BL21
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 7.54 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182634 | — | — | 1 | 9.05 |
| CHEMBL179897 | — | — | 1 | 8.80 |
| CHEMBL183705 | — | — | 1 | 8.74 |
| CHEMBL360097 | — | — | 1 | 8.72 |
| CHEMBL183442 | — | — | 1 | 8.42 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 8.10 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 8.05 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.85 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.42 |
| CHEMBL265674 | — | — | 1 | 7.22 |
| CHEMBL183450 | — | — | 1 | 7.11 |
| CHEMBL183775 | — | — | 1 | 7.09 |
| CHEMBL180943 | — | — | 1 | 7.06 |
| CHEMBL360041 | — | — | 1 | 6.98 |
| CHEMBL183763 | — | — | 1 | 6.78 |
| CHEMBL182476 | — | — | 1 | 6.76 |
| CHEMBL182637 | — | — | 1 | 6.63 |
| CHEMBL182523 | — | — | 1 | 6.59 |
| CHEMBL182185 | — | — | 1 | 6.58 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182634 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL179897 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL183705 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL360097 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL183442 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL265674 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL183450 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL183775 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL180943 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL360041 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL183763 | — | Ki | = | 165.0 | nM | 6.78 |
| CHEMBL182476 | — | Ki | = | 173.0 | nM | 6.76 |
| CHEMBL182637 | — | Ki | = | 234.0 | nM | 6.63 |
| CHEMBL182523 | — | Ki | = | 258.0 | nM | 6.59 |
| CHEMBL182185 | — | Ki | = | 265.0 | nM | 6.58 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 300.0 | nM | 6.52 |