Assay Detail
Binding
CHEMBL840158
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In vitro binding affinity against recombinant human dopamine receptor D2L in human liver microsomes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Syntheses and properties of the major hydroxy metabolites in humans of blonanserin AD-5423, a novel antipsychotic agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.42 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL178803 | BLONANSERIN | 4.0 | 1 | 9.85 |
| CHEMBL360457 | — | — | 1 | 8.44 |
| CHEMBL181469 | — | — | 1 | 8.21 |
| CHEMBL179649 | — | — | 1 | 7.92 |
| CHEMBL362285 | — | — | 1 | 7.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL178803 | BLONANSERIN | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL360457 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL181469 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL179649 | — | Ki | = | 11.9 | nM | 7.92 |
| CHEMBL362285 | — | Ki | = | 21.2 | nM | 7.67 |