Assay Detail
Binding
CHEMBL840250
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Effective concentration for mouse Melanocortin-1 receptor
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Melanocyte-stimulating hormone receptor (CHEMBL4077) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Structure-activity relationships of the unique and potent agouti-related protein (AGRP)-melanocortin chimeric Tyr-c[beta-Asp-His-DPhe-Arg-Trp-Asn-Ala-Phe-Dpr]-Tyr-NH2 peptide template.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 26 | 7.95 | 10.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | 4.0 | 1 | 10.74 |
| CHEMBL430239 | MELATONAN | — | 1 | 10.66 |
| CHEMBL2369964 | — | — | 1 | 9.70 |
| CHEMBL2369959 | — | — | 1 | 9.66 |
| CHEMBL2369973 | — | — | 1 | 9.52 |
| CHEMBL214332 | INTERMEDINE | 2.0 | 1 | 9.30 |
| CHEMBL2369963 | — | — | 1 | 9.28 |
| CHEMBL2096742 | — | — | 1 | 9.19 |
| CHEMBL2369983 | — | — | 1 | 8.58 |
| CHEMBL2369975 | — | — | 1 | 8.41 |
| CHEMBL2369974 | — | — | 1 | 8.26 |
| CHEMBL2369960 | — | — | 1 | 8.22 |
| CHEMBL2369967 | — | — | 1 | 8.14 |
| CHEMBL2369982 | — | — | 1 | 8.04 |
| CHEMBL2369965 | — | — | 1 | 7.94 |
| CHEMBL2369966 | — | — | 1 | 7.67 |
| CHEMBL2369971 | — | — | 1 | 7.66 |
| CHEMBL2369969 | — | — | 1 | 7.18 |
| CHEMBL2369970 | — | — | 1 | 6.46 |
| CHEMBL2369977 | — | — | 1 | 6.17 |
| CHEMBL2369961 | — | — | 1 | 6.16 |
| CHEMBL2369976 | — | — | 1 | 6.00 |
| CHEMBL2369962 | — | — | 1 | 6.00 |
| CHEMBL2369972 | — | — | 1 | 4.99 |
| CHEMBL2369968 | — | — | 1 | 4.85 |
| CHEMBL2096710 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | EC50 | = | 0.018 | nM | 10.74 |
| CHEMBL430239 | MELATONAN | EC50 | = | 0.022 | nM | 10.66 |
| CHEMBL2369964 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL2369959 | — | EC50 | = | 0.22 | nM | 9.66 |
| CHEMBL2369973 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL214332 | INTERMEDINE | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL2369963 | — | EC50 | = | 0.53 | nM | 9.28 |
| CHEMBL2096742 | — | EC50 | = | 0.64 | nM | 9.19 |
| CHEMBL2369983 | — | EC50 | = | 2.61 | nM | 8.58 |
| CHEMBL2369975 | — | EC50 | = | 3.87 | nM | 8.41 |
| CHEMBL2369974 | — | EC50 | = | 5.56 | nM | 8.26 |
| CHEMBL2369960 | — | EC50 | = | 6.04 | nM | 8.22 |
| CHEMBL2369967 | — | EC50 | = | 7.2 | nM | 8.14 |
| CHEMBL2369982 | — | EC50 | = | 9.2 | nM | 8.04 |
| CHEMBL2369965 | — | EC50 | = | 11.6 | nM | 7.94 |
| CHEMBL2369966 | — | EC50 | = | 21.6 | nM | 7.67 |
| CHEMBL2369971 | — | EC50 | = | 22.1 | nM | 7.66 |
| CHEMBL2369969 | — | EC50 | = | 66.5 | nM | 7.18 |
| CHEMBL2369970 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL2369977 | — | EC50 | = | 680.0 | nM | 6.17 |
| CHEMBL2369961 | — | EC50 | = | 690.0 | nM | 6.16 |
| CHEMBL2369976 | — | EC50 | = | 990.0 | nM | 6.00 |
| CHEMBL2369962 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2369972 | — | EC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL2369968 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL2096710 | — | EC50 | = | 5120.0 | nM | - |