Assay Detail
Binding
CHEMBL840252
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Effective concentration for mouse Melanocortin-4 receptor
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships of the unique and potent agouti-related protein (AGRP)-melanocortin chimeric Tyr-c[beta-Asp-His-DPhe-Arg-Trp-Asn-Ala-Phe-Dpr]-Tyr-NH2 peptide template.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 7.99 | 10.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL430239 | MELATONAN | — | 1 | 10.28 |
| CHEMBL2369959 | — | — | 1 | 9.89 |
| CHEMBL441738 | AFAMELANOTIDE | 4.0 | 1 | 9.80 |
| CHEMBL2369963 | — | — | 1 | 9.57 |
| CHEMBL2369967 | — | — | 1 | 9.44 |
| CHEMBL2369975 | — | — | 1 | 9.24 |
| CHEMBL2369982 | — | — | 1 | 9.24 |
| CHEMBL2369971 | — | — | 1 | 9.20 |
| CHEMBL2369960 | — | — | 1 | 9.19 |
| CHEMBL2369983 | — | — | 1 | 9.18 |
| CHEMBL2369964 | — | — | 1 | 9.17 |
| CHEMBL214332 | INTERMEDINE | 2.0 | 1 | 8.71 |
| CHEMBL2369969 | — | — | 1 | 7.49 |
| CHEMBL2369965 | — | — | 1 | 7.37 |
| CHEMBL2369961 | — | — | 1 | 6.94 |
| CHEMBL2369966 | — | — | 1 | 6.58 |
| CHEMBL2369970 | — | — | 1 | 6.15 |
| CHEMBL2369976 | — | — | 1 | 5.37 |
| CHEMBL2369962 | — | — | 1 | 5.14 |
| CHEMBL2369977 | — | — | 1 | 5.07 |
| CHEMBL2369972 | — | — | 1 | 4.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL430239 | MELATONAN | EC50 | = | 0.053 | nM | 10.28 |
| CHEMBL2369959 | — | EC50 | = | 0.13 | nM | 9.89 |
| CHEMBL441738 | AFAMELANOTIDE | EC50 | = | 0.16 | nM | 9.80 |
| CHEMBL2369963 | — | EC50 | = | 0.27 | nM | 9.57 |
| CHEMBL2369967 | — | EC50 | = | 0.36 | nM | 9.44 |
| CHEMBL2369975 | — | EC50 | = | 0.57 | nM | 9.24 |
| CHEMBL2369982 | — | EC50 | = | 0.57 | nM | 9.24 |
| CHEMBL2369971 | — | EC50 | = | 0.63 | nM | 9.20 |
| CHEMBL2369960 | — | EC50 | = | 0.64 | nM | 9.19 |
| CHEMBL2369983 | — | EC50 | = | 0.66 | nM | 9.18 |
| CHEMBL2369964 | — | EC50 | = | 0.67 | nM | 9.17 |
| CHEMBL214332 | INTERMEDINE | EC50 | = | 1.93 | nM | 8.71 |
| CHEMBL2369969 | — | EC50 | = | 32.5 | nM | 7.49 |
| CHEMBL2369965 | — | EC50 | = | 42.6 | nM | 7.37 |
| CHEMBL2369961 | — | EC50 | = | 115.0 | nM | 6.94 |
| CHEMBL2369966 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL2369970 | — | EC50 | = | 710.0 | nM | 6.15 |
| CHEMBL2369976 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL2369962 | — | EC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL2369977 | — | EC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL2369972 | — | EC50 | = | 16700.0 | nM | 4.78 |