Assay Detail
Functional
CHEMBL840261
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro agonist potency for Mouse Melanocortin 1 receptor
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Melanocyte-stimulating hormone receptor (CHEMBL4077) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
N-terminal fatty acylated His-dPhe-Arg-Trp-NH(2) tetrapeptides: influence of fatty acid chain length on potency and selectivity at the mouse melanocortin receptors and human melanocytes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 8.96 | 10.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | 4.0 | 1 | 10.49 |
| CHEMBL2371851 | — | — | 1 | 10.40 |
| CHEMBL191303 | — | — | 1 | 9.48 |
| CHEMBL214332 | INTERMEDINE | 2.0 | 1 | 9.40 |
| CHEMBL195439 | — | — | 1 | 9.40 |
| CHEMBL370261 | — | — | 1 | 9.24 |
| CHEMBL191304 | — | — | 1 | 9.14 |
| CHEMBL364726 | — | — | 1 | 9.08 |
| CHEMBL190366 | — | — | 1 | 9.03 |
| CHEMBL265236 | — | — | 1 | 9.00 |
| CHEMBL193151 | — | — | 1 | 8.68 |
| CHEMBL194217 | — | — | 1 | 8.55 |
| CHEMBL195468 | — | — | 1 | 8.51 |
| CHEMBL426282 | — | — | 1 | 8.48 |
| CHEMBL264190 | — | — | 1 | 7.28 |
| CHEMBL370254 | — | — | 1 | 7.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | EC50 | = | 0.032 | nM | 10.49 |
| CHEMBL2371851 | — | EC50 | = | 0.04 | nM | 10.40 |
| CHEMBL191303 | — | EC50 | = | 0.33 | nM | 9.48 |
| CHEMBL214332 | INTERMEDINE | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL195439 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL370261 | — | EC50 | = | 0.58 | nM | 9.24 |
| CHEMBL191304 | — | EC50 | = | 0.72 | nM | 9.14 |
| CHEMBL364726 | — | EC50 | = | 0.83 | nM | 9.08 |
| CHEMBL190366 | — | EC50 | = | 0.94 | nM | 9.03 |
| CHEMBL265236 | — | EC50 | = | 0.99 | nM | 9.00 |
| CHEMBL193151 | — | EC50 | = | 2.07 | nM | 8.68 |
| CHEMBL194217 | — | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL195468 | — | EC50 | = | 3.07 | nM | 8.51 |
| CHEMBL426282 | — | EC50 | = | 3.34 | nM | 8.48 |
| CHEMBL264190 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL370254 | — | EC50 | = | 67.0 | nM | 7.17 |