Assay Detail
Functional
CHEMBL840422
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of ET-1 stimulated vasoconstriction in rabbit femoral artery.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Femoral artery |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
1-benzyl-3-thioaryl-2-carboxyindoles as potent non-peptide endothelin antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 7.00 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL287169 | — | — | 1 | 7.50 |
| CHEMBL27732 | — | — | 1 | 7.30 |
| CHEMBL28920 | — | — | 1 | 6.90 |
| CHEMBL28563 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL287169 | — | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL27732 | — | Kd | = | 50.12 | nM | 7.30 |
| CHEMBL28920 | — | Kd | = | 125.89 | nM | 6.90 |
| CHEMBL28563 | — | Kd | = | 501.19 | nM | 6.30 |