Assay Detail
Functional
CHEMBL840722
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In Vitro cytotoxicity against human stomach cancer cell line (MKN45)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MKN-45 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of novel A-ring modified hexacyclic camptothecin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.04 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | 2.0 | 1 | 8.10 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.77 |
| CHEMBL445883 | — | — | 1 | 7.72 |
| CHEMBL297811 | — | — | 1 | 7.72 |
| CHEMBL44044 | — | — | 1 | 7.70 |
| CHEMBL289665 | — | — | 1 | 7.70 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 7.42 |
| CHEMBL296862 | — | — | 1 | 7.40 |
| CHEMBL288053 | — | — | 1 | 6.82 |
| CHEMBL41652 | — | — | 1 | 6.27 |
| CHEMBL297040 | — | — | 1 | 5.02 |
| CHEMBL290652 | — | — | 1 | 4.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL445883 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL297811 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL44044 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL289665 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL296862 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL288053 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL41652 | — | IC50 | = | 536.0 | nM | 6.27 |
| CHEMBL297040 | — | IC50 | = | 9571.0 | nM | 5.02 |
| CHEMBL290652 | — | IC50 | = | 15414.0 | nM | 4.81 |