Assay Detail
Functional
CHEMBL840833
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Concentration required to inhibit tubulin polymerization at 10 uM
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and preliminary biological evaluation of new anti-tubulin agents containing different benzoheterocycles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.62 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190320 | — | — | 1 | 5.89 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.70 |
| CHEMBL189355 | — | — | 1 | 5.51 |
| CHEMBL371795 | — | — | 1 | 5.38 |
| CHEMBL362315 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190320 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL189355 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL371795 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL362315 | — | IC50 | > | 40000.0 | nM | - |