Assay Detail
Functional
CHEMBL840937
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity against histamine H1 receptor
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Use of CoMFA in validating the conformation used in designing 4-(1H-benzimidazole-2-carbonyl)piperidines with H1/NK1 receptor antagonist activity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 8.21 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL411691 | — | — | 1 | 8.35 |
| CHEMBL273915 | — | — | 1 | 8.34 |
| CHEMBL94788 | — | — | 1 | 8.30 |
| CHEMBL430471 | — | — | 1 | 8.30 |
| CHEMBL96441 | — | — | 1 | 8.24 |
| CHEMBL328511 | — | — | 1 | 8.23 |
| CHEMBL95029 | — | — | 1 | 8.22 |
| CHEMBL318369 | — | — | 1 | 8.22 |
| CHEMBL95243 | — | — | 1 | 8.22 |
| CHEMBL327888 | — | — | 1 | 8.21 |
| CHEMBL330499 | — | — | 1 | 8.20 |
| CHEMBL94834 | — | — | 1 | 8.20 |
| CHEMBL97240 | — | — | 1 | 8.20 |
| CHEMBL95076 | — | — | 1 | 8.20 |
| CHEMBL264007 | — | — | 1 | 8.20 |
| CHEMBL330172 | — | — | 1 | 8.20 |
| CHEMBL94480 | — | — | 1 | 8.20 |
| CHEMBL93519 | — | — | 1 | 8.20 |
| CHEMBL95125 | — | — | 1 | 8.20 |
| CHEMBL322194 | — | — | 1 | 8.19 |
| CHEMBL320003 | — | — | 1 | 8.19 |
| CHEMBL93556 | — | — | 1 | 8.19 |
| CHEMBL96141 | — | — | 1 | 8.19 |
| CHEMBL96442 | — | — | 1 | 8.19 |
| CHEMBL95127 | — | — | 1 | 8.19 |
| CHEMBL98079 | — | — | 1 | 8.18 |
| CHEMBL319535 | — | — | 1 | 8.18 |
| CHEMBL94906 | — | — | 1 | 8.18 |
| CHEMBL329055 | — | — | 1 | 8.18 |
| CHEMBL94726 | — | — | 1 | 8.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL411691 | — | IC50 | = | 4.47 | nM | 8.35 |
| CHEMBL273915 | — | IC50 | = | 4.56 | nM | 8.34 |
| CHEMBL94788 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL430471 | — | IC50 | = | 5.04 | nM | 8.30 |
| CHEMBL96441 | — | IC50 | = | 5.71 | nM | 8.24 |
| CHEMBL328511 | — | IC50 | = | 5.93 | nM | 8.23 |
| CHEMBL95029 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL318369 | — | IC50 | = | 6.02 | nM | 8.22 |
| CHEMBL95243 | — | IC50 | = | 6.02 | nM | 8.22 |
| CHEMBL327888 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL93519 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL94834 | — | IC50 | = | 6.33 | nM | 8.20 |
| CHEMBL97240 | — | IC50 | = | 6.26 | nM | 8.20 |
| CHEMBL95076 | — | IC50 | = | 6.35 | nM | 8.20 |
| CHEMBL330499 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL264007 | — | IC50 | = | 6.36 | nM | 8.20 |
| CHEMBL330172 | — | IC50 | = | 6.38 | nM | 8.20 |
| CHEMBL94480 | — | IC50 | = | 6.25 | nM | 8.20 |
| CHEMBL95125 | — | IC50 | = | 6.36 | nM | 8.20 |
| CHEMBL322194 | — | IC50 | = | 6.42 | nM | 8.19 |
| CHEMBL95127 | — | IC50 | = | 6.53 | nM | 8.19 |
| CHEMBL96442 | — | IC50 | = | 6.44 | nM | 8.19 |
| CHEMBL96141 | — | IC50 | = | 6.47 | nM | 8.19 |
| CHEMBL93556 | — | IC50 | = | 6.48 | nM | 8.19 |
| CHEMBL320003 | — | IC50 | = | 6.39 | nM | 8.19 |
| CHEMBL98079 | — | IC50 | = | 6.63 | nM | 8.18 |
| CHEMBL319535 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL94906 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL329055 | — | IC50 | = | 6.67 | nM | 8.18 |
| CHEMBL94726 | — | IC50 | = | 6.59 | nM | 8.18 |
| CHEMBL327497 | — | IC50 | = | 6.62 | nM | 8.18 |
| CHEMBL330719 | — | IC50 | = | 6.55 | nM | 8.18 |
| CHEMBL320002 | — | IC50 | = | 6.69 | nM | 8.18 |
| CHEMBL97357 | — | IC50 | = | 6.55 | nM | 8.18 |
| CHEMBL330462 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL96466 | — | IC50 | = | 6.89 | nM | 8.16 |
| CHEMBL95051 | — | IC50 | = | 7.23 | nM | 8.14 |
| CHEMBL98076 | — | IC50 | = | 7.33 | nM | 8.13 |