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Assay Detail

CHEMBL841023

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]p-iodoclonidine from imidazoline receptor I-1 of PC12 cell membranes
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Cell Type PC-12
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Nischarin (CHEMBL3923)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

2-(2-Phenylcyclopropyl)imidazolines: reversed enantioselective interaction at I(1) and I(2) imidazoline receptors.
Quaglia W, Bousquet P, Pigini M, Carotti A, Carrieri A, Dontenwill M, Gentili F, Giannella M, Maranca F, Piergentili A, Brasili L.
J Med Chem (1999) 42 : 2737 -2740
PubMed 10425083 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 7.72 7.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL275970 TRACIZOLINE 1 7.72

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL275970 TRACIZOLINE Ki = 19.05 nM 7.72