Assay Detail
Binding
CHEMBL841024
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Displacement of [125I]p-iodoclonidine from imidazoline receptor I-1 of PC12 cell membranes
7
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | PC-12 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2-(2-Phenylcyclopropyl)imidazolines: reversed enantioselective interaction at I(1) and I(2) imidazoline receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.08 | 7.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94022 | — | — | 2 | 7.93 |
| CHEMBL67706 | — | — | 3 | 7.76 |
| CHEMBL93845 | — | — | 1 | 6.46 |
| CHEMBL275970 | TRACIZOLINE | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94022 | — | Ki | = | 11.75 | nM | 7.93 |
| CHEMBL67706 | — | Ki | = | 17.38 | nM | 7.76 |
| CHEMBL93845 | — | Ki | = | 346.74 | nM | 6.46 |
| CHEMBL275970 | TRACIZOLINE | Ki | = | 3801.89 | nM | 5.42 |
| CHEMBL67706 | — | Ki | = | 5495.41 | nM | 5.26 |
| CHEMBL67706 | — | Ki | = | 5754.4 | nM | 5.24 |
| CHEMBL94022 | — | Ki | = | 30902.95 | nM | 4.51 |