Assay Detail
Binding
CHEMBL841199
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Inhibition of human p56 Lck tyrosine kinase (lck64-509)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pyrrolo[2,3-d]pyrimidines containing diverse N-7 substituents as potent inhibitors of Lck.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.90 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL47203 | — | — | 1 | 7.82 |
| CHEMBL48554 | — | — | 1 | 7.38 |
| CHEMBL296534 | — | — | 1 | 7.34 |
| CHEMBL44942 | — | — | 1 | 7.09 |
| CHEMBL47940 | — | — | 1 | 7.00 |
| CHEMBL296103 | — | — | 1 | 6.92 |
| CHEMBL297359 | — | — | 1 | 6.89 |
| CHEMBL47202 | — | — | 1 | 6.77 |
| CHEMBL45177 | — | — | 1 | 6.62 |
| CHEMBL297278 | — | — | 1 | 6.62 |
| CHEMBL431342 | — | — | 1 | 6.28 |
| CHEMBL416444 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL47203 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL48554 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL296534 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL44942 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL47940 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL296103 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL297359 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL47202 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL45177 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL297278 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL431342 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL416444 | — | IC50 | = | 890.0 | nM | 6.05 |