Assay Detail
Binding
CHEMBL841200
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Inhibition of p56 Lck tyrosine kinase in Jurkat cells where p56lck autophosphorylation is inhibited.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Jurkat |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
The preparation and sar of 4-(anilino), 4-(phenoxy), and 4-(thiophenoxy)-quinazolines: Inhibitors of p56lck and EGF-R tyrosine kinase activity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.66 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL406845 | — | — | 1 | 8.40 |
| CHEMBL306380 | — | — | 1 | 8.30 |
| CHEMBL212948 | DAMNACANTHAL | — | 1 | 7.77 |
| CHEMBL555201 | — | — | 1 | 5.52 |
| CHEMBL335400 | — | — | 1 | 5.30 |
| CHEMBL541586 | — | — | 1 | 5.00 |
| CHEMBL544833 | — | — | 1 | 5.00 |
| CHEMBL542729 | — | — | 1 | 5.00 |
| CHEMBL542733 | — | — | 1 | 5.00 |
| CHEMBL539552 | — | — | 1 | 5.00 |
| CHEMBL545541 | — | — | 1 | 4.70 |
| CHEMBL555797 | — | — | 1 | 4.30 |
| CHEMBL538528 | — | — | 1 | 4.30 |
| CHEMBL544836 | — | — | 1 | - |
| CHEMBL542237 | — | — | 1 | - |
| CHEMBL545767 | — | — | 1 | - |
| CHEMBL555844 | — | — | 1 | - |
| CHEMBL132605 | — | — | 1 | - |
| CHEMBL543429 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL406845 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL306380 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL212948 | DAMNACANTHAL | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL555201 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL335400 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL541586 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL544833 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL542729 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL542733 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL539552 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL545541 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL555797 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL538528 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL544836 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL542237 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL545767 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL555844 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL132605 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL543429 | — | IC50 | > | 100000.0 | nM | - |