Assay Detail
Binding
CHEMBL841209
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Inhibition of p56 Lck tyrosine kinase catalytic domain at 1 mM ATP
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.15 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69827 | — | — | 1 | 6.50 |
| CHEMBL69129 | — | — | 1 | 6.26 |
| CHEMBL47940 | — | — | 1 | 5.97 |
| CHEMBL419082 | — | — | 1 | 5.88 |
| CHEMBL69638 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69827 | — | IC50 | = | 317.0 | nM | 6.50 |
| CHEMBL69129 | — | IC50 | = | 544.0 | nM | 6.26 |
| CHEMBL47940 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL419082 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL69638 | — | IC50 | > | 10000.0 | nM | - |