Assay Detail
Functional
CHEMBL841272
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of sarafotoxin-6c stimulated vasoconstriction in rabbit pulmonary artery.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
1-benzyl-3-thioaryl-2-carboxyindoles as potent non-peptide endothelin antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 5.97 | 6.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28563 | — | — | 1 | 6.20 |
| CHEMBL27732 | — | — | 1 | 6.20 |
| CHEMBL287169 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28563 | — | Kd | = | 630.96 | nM | 6.20 |
| CHEMBL27732 | — | Kd | = | 630.96 | nM | 6.20 |
| CHEMBL287169 | — | Kd | = | 3162.28 | nM | 5.50 |