Assay Detail
Binding
CHEMBL841761
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Binding affinity for human immunodeficiency virus type 1 protease
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Improved structure-activity relationship analysis of HIV-1 protease inhibitors using interaction kinetic data.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 27 | 7.91 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | 10.00 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 9.51 |
| CHEMBL1163 | ATAZANAVIR | 4.0 | 1 | 9.40 |
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 9.22 |
| CHEMBL1161738 | — | — | 1 | 9.19 |
| CHEMBL5483011 | INDINAVIR | 3.0 | 1 | 8.97 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 8.96 |
| CHEMBL1161743 | — | — | 1 | 8.93 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 8.79 |
| CHEMBL1161737 | — | — | 1 | 8.71 |
| CHEMBL365756 | — | — | 1 | 8.52 |
| CHEMBL1161736 | — | — | 1 | 8.36 |
| CHEMBL1161734 | — | — | 1 | 7.97 |
| CHEMBL1161742 | — | — | 1 | 7.86 |
| CHEMBL1161741 | — | — | 1 | 7.76 |
| CHEMBL610244 | — | — | 1 | 7.74 |
| CHEMBL1161732 | — | — | 1 | 7.68 |
| CHEMBL1161733 | — | — | 1 | 7.47 |
| CHEMBL425182 | — | — | 1 | 7.45 |
| CHEMBL340616 | — | — | 1 | 7.40 |
| CHEMBL190112 | — | — | 1 | 6.77 |
| CHEMBL150908 | — | — | 1 | 6.44 |
| CHEMBL345603 | — | — | 1 | 6.38 |
| CHEMBL443 | SULFAMETHOXAZOLE | 4.0 | 1 | 6.24 |
| CHEMBL1161735 | — | — | 1 | 5.52 |
| CHEMBL1161739 | — | — | 1 | 4.42 |
| CHEMBL1161740 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL729 | LOPINAVIR | Kd | = | 0.1 | nM | 10.00 |
| CHEMBL114 | SAQUINAVIR | Kd | = | 0.31 | nM | 9.51 |
| CHEMBL1163 | ATAZANAVIR | Kd | = | 0.4 | nM | 9.40 |
| CHEMBL163 | RITONAVIR | Kd | = | 0.6 | nM | 9.22 |
| CHEMBL1161738 | — | Kd | = | 0.64 | nM | 9.19 |
| CHEMBL5483011 | INDINAVIR | Kd | = | 1.07 | nM | 8.97 |
| CHEMBL116 | AMPRENAVIR | Kd | = | 1.1 | nM | 8.96 |
| CHEMBL1161743 | — | Kd | = | 1.18 | nM | 8.93 |
| CHEMBL584 | NELFINAVIR | Kd | = | 1.64 | nM | 8.79 |
| CHEMBL1161737 | — | Kd | = | 1.95 | nM | 8.71 |
| CHEMBL365756 | — | Kd | = | 3.04 | nM | 8.52 |
| CHEMBL1161736 | — | Kd | = | 4.42 | nM | 8.36 |
| CHEMBL1161734 | — | Kd | = | 10.8 | nM | 7.97 |
| CHEMBL1161742 | — | Kd | = | 13.9 | nM | 7.86 |
| CHEMBL1161741 | — | Kd | = | 17.5 | nM | 7.76 |
| CHEMBL610244 | — | Kd | = | 18.2 | nM | 7.74 |
| CHEMBL1161732 | — | Kd | = | 21.1 | nM | 7.68 |
| CHEMBL1161733 | — | Kd | = | 34.2 | nM | 7.47 |
| CHEMBL425182 | — | Kd | = | 35.8 | nM | 7.45 |
| CHEMBL340616 | — | Kd | = | 39.8 | nM | 7.40 |
| CHEMBL190112 | — | Kd | = | 169.0 | nM | 6.77 |
| CHEMBL150908 | — | Kd | = | 366.0 | nM | 6.44 |
| CHEMBL345603 | — | Kd | = | 420.0 | nM | 6.38 |
| CHEMBL443 | SULFAMETHOXAZOLE | Kd | = | 577.0 | nM | 6.24 |
| CHEMBL1161735 | — | Kd | = | 2990.0 | nM | 5.52 |
| CHEMBL1161739 | — | Kd | = | 38400.0 | nM | 4.42 |
| CHEMBL1161740 | — | Kd | = | 309000.0 | nM | - |