Assay Detail
Binding
CHEMBL841778
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Inhibition of [3H]SR-141,716A binding to human CB1 receptor expressed in CHO cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Substituted 5,5'-diphenyl-2-thioxoimidazolidin-4-one as CB1 cannabinoid receptor ligands: synthesis and pharmacological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 5.97 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL111 | RIMONABANT | 4.0 | 1 | 8.27 |
| CHEMBL334533 | DEXANABINOL | 3.0 | 1 | 7.73 |
| CHEMBL190316 | — | — | 1 | 6.23 |
| CHEMBL195445 | — | — | 1 | 6.14 |
| CHEMBL192991 | — | — | 1 | 6.06 |
| CHEMBL192436 | — | — | 1 | 6.00 |
| CHEMBL364312 | — | — | 1 | 5.85 |
| CHEMBL365241 | — | — | 1 | 5.76 |
| CHEMBL192958 | — | — | 1 | 5.75 |
| CHEMBL426455 | — | — | 1 | 5.74 |
| CHEMBL195396 | — | — | 1 | 5.68 |
| CHEMBL189056 | — | — | 1 | 5.66 |
| CHEMBL190043 | — | — | 1 | 5.66 |
| CHEMBL189160 | — | — | 1 | 5.46 |
| CHEMBL371614 | — | — | 1 | 5.44 |
| CHEMBL434941 | — | — | 1 | 5.42 |
| CHEMBL188 | WIN-552122 | — | 1 | 5.42 |
| CHEMBL190411 | — | — | 1 | 5.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL111 | RIMONABANT | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL334533 | DEXANABINOL | Ki | = | 18.6 | nM | 7.73 |
| CHEMBL190316 | — | Ki | = | 589.0 | nM | 6.23 |
| CHEMBL195445 | — | Ki | = | 724.0 | nM | 6.14 |
| CHEMBL192991 | — | Ki | = | 871.0 | nM | 6.06 |
| CHEMBL192436 | — | Ki | = | 993.0 | nM | 6.00 |
| CHEMBL364312 | — | Ki | = | 1412.0 | nM | 5.85 |
| CHEMBL365241 | — | Ki | = | 1738.0 | nM | 5.76 |
| CHEMBL192958 | — | Ki | = | 1778.0 | nM | 5.75 |
| CHEMBL426455 | — | Ki | = | 1820.0 | nM | 5.74 |
| CHEMBL195396 | — | Ki | = | 2089.0 | nM | 5.68 |
| CHEMBL189056 | — | Ki | = | 2193.0 | nM | 5.66 |
| CHEMBL190043 | — | Ki | = | 2188.0 | nM | 5.66 |
| CHEMBL189160 | — | Ki | = | 3467.0 | nM | 5.46 |
| CHEMBL371614 | — | Ki | = | 3630.0 | nM | 5.44 |
| CHEMBL434941 | — | Ki | = | 3801.0 | nM | 5.42 |
| CHEMBL188 | WIN-552122 | Ki | = | 3802.0 | nM | 5.42 |
| CHEMBL190411 | — | Ki | = | 5495.0 | nM | 5.26 |