Assay Detail
Binding
CHEMBL841779
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against human carbonic anhydrase II
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 7.72 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 8.52 |
| CHEMBL179355 | — | — | 1 | 8.22 |
| CHEMBL181082 | — | — | 1 | 8.22 |
| CHEMBL180177 | THIOUREIDO SULFONAMIDE | — | 1 | 8.15 |
| CHEMBL178403 | — | — | 1 | 8.15 |
| CHEMBL178560 | — | — | 1 | 8.10 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 8.10 |
| CHEMBL538564 | — | — | 1 | 8.05 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 8.05 |
| CHEMBL182197 | — | — | 1 | 8.00 |
| CHEMBL181422 | — | — | 1 | 7.96 |
| CHEMBL180506 | — | — | 1 | 7.92 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL182135 | — | — | 1 | 7.89 |
| CHEMBL181825 | — | — | 1 | 7.89 |
| CHEMBL178603 | — | — | 1 | 7.85 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.85 |
| CHEMBL180936 | — | — | 1 | 7.80 |
| CHEMBL361955 | — | — | 1 | 7.75 |
| CHEMBL362636 | — | — | 1 | 7.72 |
| CHEMBL361827 | — | — | 1 | 7.60 |
| CHEMBL413357 | — | — | 1 | 7.57 |
| CHEMBL179218 | — | — | 1 | 7.48 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.42 |
| CHEMBL360254 | — | — | 1 | 7.32 |
| CHEMBL181716 | — | — | 1 | 7.12 |
| CHEMBL178664 | THIOUREIDO SULFONAMIDE | — | 1 | 6.82 |
| CHEMBL180195 | — | — | 1 | 6.80 |
| CHEMBL180675 | THIOUREIDO SULFONAMIDE | — | 1 | 6.73 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL179355 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL181082 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL180177 | THIOUREIDO SULFONAMIDE | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL178403 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL178560 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL538564 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL182197 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL181422 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL180506 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL182135 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL181825 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL178603 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL180936 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL361955 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL362636 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL361827 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL413357 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL179218 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL360254 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL181716 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL178664 | THIOUREIDO SULFONAMIDE | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL180195 | — | Ki | = | 159.0 | nM | 6.80 |
| CHEMBL180675 | THIOUREIDO SULFONAMIDE | Ki | = | 185.0 | nM | 6.73 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 300.0 | nM | 6.52 |