Assay Detail
Functional
CHEMBL841914
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against cap-dependent endonuclease activity of influenza B/Lee/40 RNP
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza B virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polymerase acidic protein (CHEMBL2028641) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza B virus (strain B/Lee/1940) |
Publication
Use of a pharmacophore model to discover a new class of influenza endonuclease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.67 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16525 | — | — | 1 | 5.22 |
| CHEMBL16377 | — | — | 1 | 4.75 |
| CHEMBL277536 | — | — | 1 | 4.58 |
| CHEMBL16239 | — | — | 1 | 4.54 |
| CHEMBL275631 | — | — | 1 | 4.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16525 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL16377 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL277536 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL16239 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL275631 | — | IC50 | = | 56000.0 | nM | 4.25 |