Assay Detail
Binding
CHEMBL842015
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Inhibition of p56 Lck tyrosine kinase catalytic domain at 5 uM ATP
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.56 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL47940 | — | — | 1 | 8.70 |
| CHEMBL69827 | — | — | 1 | 8.30 |
| CHEMBL307982 | — | — | 1 | 8.00 |
| CHEMBL302281 | — | — | 1 | 7.86 |
| CHEMBL306380 | — | — | 1 | 6.60 |
| CHEMBL69638 | — | — | 1 | 5.92 |
| CHEMBL419082 | — | — | 1 | - |
| CHEMBL69129 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL47940 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL69827 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL307982 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL302281 | — | IC50 | = | 13.8 | nM | 7.86 |
| CHEMBL306380 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL69638 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL419082 | — | IC50 | < | 8.0 | nM | - |
| CHEMBL69129 | — | IC50 | < | 1.0 | nM | - |