Assay Detail
Binding
CHEMBL842016
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Inhibition of p56 Lck tyrosine kinase (catalytic domain)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.22 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL47940 | — | — | 1 | 8.70 |
| CHEMBL307982 | — | — | 1 | 8.00 |
| CHEMBL302281 | — | — | 1 | 7.85 |
| CHEMBL433097 | — | — | 1 | 7.82 |
| CHEMBL302481 | — | — | 1 | 7.77 |
| CHEMBL69068 | — | — | 1 | 7.72 |
| CHEMBL66102 | — | — | 1 | 7.70 |
| CHEMBL304113 | — | — | 1 | 7.42 |
| CHEMBL68430 | — | — | 1 | 7.22 |
| CHEMBL69649 | — | — | 1 | 7.16 |
| CHEMBL303195 | — | — | 1 | 6.82 |
| CHEMBL67268 | — | — | 1 | 6.48 |
| CHEMBL68888 | — | — | 1 | 6.04 |
| CHEMBL68082 | — | — | 1 | 6.03 |
| CHEMBL66716 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL47940 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL307982 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL302281 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL433097 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL302481 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL69068 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL66102 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL304113 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL68430 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL69649 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL303195 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL67268 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL68888 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL68082 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL66716 | — | IC50 | = | 2290.0 | nM | 5.64 |