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Assay Detail

CHEMBL842087

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human sst2 receptor expressed in CHO cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Expert

Target

Somatostatin receptor type 2 (CHEMBL1804)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Novel non-peptide ligands for the somatostatin sst3 receptor.
Moinet C, Contour-Galcéra MO, Poitout L, Morgan B, Gordon T, Rouber P, Thurieau C.
Bioorg Med Chem Lett (2001) 11 : 991 -995
PubMed 11327607 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 5.98 10.31

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1823872 SOMATOSTATIN 3.0 1 10.31
CHEMBL362859 1 5.46
CHEMBL176313 1 5.38
CHEMBL176730 1 5.23
CHEMBL367699 1 5.22
CHEMBL368334 1 5.21
CHEMBL174872 1 5.06
CHEMBL368176 1 -
CHEMBL175356 1 -
CHEMBL368993 1 -
CHEMBL175197 1 -
CHEMBL367716 1 -
CHEMBL174490 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1823872 SOMATOSTATIN Ki = 0.049 nM 10.31
CHEMBL362859 Ki = 3470.0 nM 5.46
CHEMBL176313 Ki = 4220.0 nM 5.38
CHEMBL176730 Ki = 5920.0 nM 5.23
CHEMBL367699 Ki = 6040.0 nM 5.22
CHEMBL368334 Ki = 6180.0 nM 5.21
CHEMBL174872 Ki = 8680.0 nM 5.06
CHEMBL368176 Ki > 10000.0 nM -
CHEMBL175356 Ki > 10000.0 nM -
CHEMBL368993 Ki > 10000.0 nM -
CHEMBL175197 Ki > 10000.0 nM -
CHEMBL367716 Ki > 10000.0 nM -
CHEMBL174490 Ki > 10000.0 nM -