Assay Detail
Binding
CHEMBL842154
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of plasminogen activator urokinase.
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Urokinase-type plasminogen activator (CHEMBL3286) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
4-amidinobenzylamine-based inhibitors of urokinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 5.76 | 8.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL158405 | — | — | 1 | 8.11 |
| CHEMBL158939 | — | — | 1 | 7.89 |
| CHEMBL158936 | — | — | 1 | 7.44 |
| CHEMBL433510 | — | — | 1 | 7.37 |
| CHEMBL158814 | — | — | 1 | 7.32 |
| CHEMBL159162 | — | — | 1 | 6.41 |
| CHEMBL415741 | — | — | 1 | 6.31 |
| CHEMBL345435 | — | — | 1 | 6.30 |
| CHEMBL346117 | — | — | 1 | 5.92 |
| CHEMBL157131 | — | — | 1 | 5.82 |
| CHEMBL352009 | — | — | 1 | 5.66 |
| CHEMBL422533 | — | — | 1 | 5.40 |
| CHEMBL440919 | — | — | 1 | 5.05 |
| CHEMBL156858 | — | — | 1 | 5.04 |
| CHEMBL423246 | — | — | 1 | 5.02 |
| CHEMBL160944 | — | — | 1 | 4.92 |
| CHEMBL345236 | — | — | 1 | 4.68 |
| CHEMBL2371217 | — | — | 1 | 4.66 |
| CHEMBL350657 | — | — | 1 | 4.64 |
| CHEMBL349545 | — | — | 1 | 4.39 |
| CHEMBL157479 | — | — | 1 | 4.21 |
| CHEMBL160580 | — | — | 1 | 4.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL158405 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL158939 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL158936 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL433510 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL158814 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL159162 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL415741 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL345435 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL346117 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL157131 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL352009 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL422533 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL440919 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL156858 | — | Ki | = | 9200.0 | nM | 5.04 |
| CHEMBL423246 | — | Ki | = | 9600.0 | nM | 5.02 |
| CHEMBL160944 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL345236 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL2371217 | — | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL350657 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL349545 | — | Ki | = | 41000.0 | nM | 4.39 |
| CHEMBL157479 | — | Ki | = | 61000.0 | nM | 4.21 |
| CHEMBL160580 | — | Ki | = | 82000.0 | nM | 4.09 |