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Assay Detail

CHEMBL842386

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Functional
Normalised IC50 was measured
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Structure-activity relationships in 4-aminoquinoline antiplasmodials. The role of the group at the 7-position.
Kaschula CH, Egan TJ, Hunter R, Basilico N, Parapini S, Taramelli D, Pasini E, Monti D.
J Med Chem (2002) 45 : 3531 -3539
PubMed 12139464 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 7.06 7.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL332186 1 7.77
CHEMBL317364 1 7.64
CHEMBL118741 1 7.55
CHEMBL324051 1 7.55
CHEMBL116204 1 7.32
CHEMBL119457 1 7.13
CHEMBL118743 1 7.04
CHEMBL119049 1 6.40
CHEMBL120140 1 6.16
CHEMBL99170 1 6.05
CHEMBL116154 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL332186 IC50 = 17.0 nM 7.77
CHEMBL317364 IC50 = 23.0 nM 7.64
CHEMBL118741 IC50 = 28.0 nM 7.55
CHEMBL324051 IC50 = 28.0 nM 7.55
CHEMBL116204 IC50 = 48.0 nM 7.32
CHEMBL119457 IC50 = 74.0 nM 7.13
CHEMBL118743 IC50 = 92.0 nM 7.04
CHEMBL119049 IC50 = 399.0 nM 6.40
CHEMBL120140 IC50 = 700.0 nM 6.16
CHEMBL99170 IC50 = 892.0 nM 6.05
CHEMBL116154 IC50 > 4830.0 nM -