Assay Detail
Binding
CHEMBL842748
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]idazoxan from imidazoline receptor I-2 of rabbit kidney membranes
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Imidazoline binding sites (IBS) profile modulation: key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.08 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14640 | — | — | 1 | 9.05 |
| CHEMBL275970 | TRACIZOLINE | — | 1 | 8.72 |
| CHEMBL14210 | PHENYZOLINE | — | 1 | 8.60 |
| CHEMBL93845 | — | — | 1 | 8.22 |
| CHEMBL67706 | — | — | 1 | 7.64 |
| CHEMBL2092860 | — | — | 1 | 7.00 |
| CHEMBL94022 | — | — | 1 | 6.91 |
| CHEMBL68608 | — | — | 1 | 6.91 |
| CHEMBL2092861 | — | — | 1 | 6.84 |
| CHEMBL71429 | — | — | 1 | 6.03 |
| CHEMBL1907831 | — | — | 1 | 5.60 |
| CHEMBL273485 | — | — | 1 | 5.57 |
| CHEMBL1907832 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14640 | — | Ki | = | 0.8913 | nM | 9.05 |
| CHEMBL275970 | TRACIZOLINE | Ki | = | 1.905 | nM | 8.72 |
| CHEMBL14210 | PHENYZOLINE | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL93845 | — | Ki | = | 6.026 | nM | 8.22 |
| CHEMBL67706 | — | Ki | = | 22.91 | nM | 7.64 |
| CHEMBL2092860 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL94022 | — | Ki | = | 123.03 | nM | 6.91 |
| CHEMBL68608 | — | Ki | = | 123.03 | nM | 6.91 |
| CHEMBL2092861 | — | Ki | = | 144.54 | nM | 6.84 |
| CHEMBL71429 | — | Ki | = | 933.25 | nM | 6.03 |
| CHEMBL1907831 | — | Ki | = | 2511.89 | nM | 5.60 |
| CHEMBL273485 | — | Ki | = | 2691.53 | nM | 5.57 |
| CHEMBL1907832 | — | Ki | = | 12589.25 | nM | 4.90 |