Assay Detail
Binding
CHEMBL842750
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Displacement of [3H]idazoxan from imidazoline receptor I-2 of rabbit kidney membranes
5
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
2-(2-Phenylcyclopropyl)imidazolines: reversed enantioselective interaction at I(1) and I(2) imidazoline receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.51 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275970 | TRACIZOLINE | — | 1 | 8.72 |
| CHEMBL93845 | — | — | 1 | 8.22 |
| CHEMBL67706 | — | — | 2 | 7.64 |
| CHEMBL94022 | — | — | 1 | 6.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275970 | TRACIZOLINE | Ki | = | 1.905 | nM | 8.72 |
| CHEMBL93845 | — | Ki | = | 6.026 | nM | 8.22 |
| CHEMBL67706 | — | Ki | = | 22.91 | nM | 7.64 |
| CHEMBL94022 | — | Ki | = | 123.03 | nM | 6.91 |
| CHEMBL67706 | — | Ki | = | 891.25 | nM | 6.05 |