Assay Detail
Binding
CHEMBL843656
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Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
36
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and discovery of a novel CCR1 antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 7.44 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL277930 | — | — | 4 | 9.05 |
| CHEMBL289902 | — | — | 1 | 8.72 |
| CHEMBL34732 | — | — | 1 | 8.70 |
| CHEMBL32257 | — | — | 1 | 8.60 |
| CHEMBL33050 | — | — | 1 | 8.55 |
| CHEMBL418589 | — | — | 1 | 8.51 |
| CHEMBL33340 | — | — | 1 | 8.48 |
| CHEMBL33614 | — | — | 1 | 8.44 |
| CHEMBL33223 | — | — | 1 | 8.41 |
| CHEMBL32713 | — | — | 1 | 8.30 |
| CHEMBL280751 | — | — | 1 | 8.28 |
| CHEMBL33104 | — | — | 1 | 8.01 |
| CHEMBL34165 | — | — | 1 | 7.85 |
| CHEMBL33929 | — | — | 1 | 7.77 |
| CHEMBL34166 | BERLEX COMPOUND | — | 1 | 7.32 |
| CHEMBL33277 | — | — | 1 | 7.29 |
| CHEMBL33074 | — | — | 1 | 6.85 |
| CHEMBL33580 | — | — | 1 | 6.82 |
| CHEMBL34053 | — | — | 1 | 6.70 |
| CHEMBL33639 | — | — | 1 | 6.62 |
| CHEMBL33586 | — | — | 1 | 6.43 |
| CHEMBL34226 | — | — | 1 | 6.29 |
| CHEMBL33761 | — | — | 1 | 6.10 |
| CHEMBL285703 | — | — | 1 | 6.10 |
| CHEMBL286355 | — | — | 1 | 5.96 |
| CHEMBL33159 | — | — | 1 | 5.80 |
| CHEMBL289682 | — | — | 1 | 5.75 |
| CHEMBL433232 | — | — | 1 | 5.68 |
| CHEMBL32305 | — | — | 1 | 5.29 |
| CHEMBL286701 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL277930 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL277930 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL277930 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL289902 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL34732 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL32257 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL33050 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL418589 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL33340 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL33614 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL33223 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL32713 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL280751 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL33104 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL34165 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL33929 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL277930 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL34166 | BERLEX COMPOUND | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL33277 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL33074 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL33580 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL34053 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL33639 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL33586 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL34226 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL33761 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL285703 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL286355 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL33159 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL289682 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL433232 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL32305 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL33278 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL289464 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL32766 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL286701 | — | IC50 | > | 10000.0 | nM | - |