Assay Detail
Functional
CHEMBL843662
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity of peptidic agonists on h-CRF2-alpha receptor using agonist-stimulated adenylate cyclase assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Corticotropin-releasing factor receptor 2 (CHEMBL4069) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Corticotropin releasing factor (CRF) receptor modulators: progress and opportunities for new therapeutic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 8.45 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL427807 | — | — | 1 | 9.49 |
| CHEMBL429560 | — | — | 1 | 8.85 |
| CHEMBL2373995 | — | — | 1 | 8.82 |
| CHEMBL2372650 | — | — | 1 | 7.88 |
| CHEMBL1077301 | — | — | 1 | 7.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL427807 | — | EC50 | = | 0.32 | nM | 9.49 |
| CHEMBL429560 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL2373995 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL2372650 | — | EC50 | = | 13.2 | nM | 7.88 |
| CHEMBL1077301 | — | EC50 | = | 61.9 | nM | 7.21 |