Assay Detail
Binding
CHEMBL843813
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Inhibitory activity against recombinant rat nNOS.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Reduced amide bond peptidomimetics. (4S)-N-(4-amino-5-[aminoakyl]aminopentyl)-N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.51 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL227937 | — | — | 1 | 6.92 |
| CHEMBL44833 | — | — | 1 | 6.89 |
| CHEMBL313228 | — | — | 1 | 6.54 |
| CHEMBL1202106 | — | — | 1 | 6.48 |
| CHEMBL91256 | — | — | 1 | 6.46 |
| CHEMBL88107 | — | — | 1 | 6.35 |
| CHEMBL92493 | — | — | 1 | 6.34 |
| CHEMBL92208 | — | — | 1 | 6.34 |
| CHEMBL88267 | — | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL227937 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL44833 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL313228 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL1202106 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL91256 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL88107 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL92493 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL92208 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL88267 | — | Ki | = | 540.0 | nM | 6.27 |