Assay Detail
Binding
CHEMBL843949
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tyrosine phosphorylation activity of the pp60v-src tyrosine kinase, protein from v-src baculovirus-infected insect cells
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Tyrosine kinase inhibitors. 3. Structure-activity relationships for inhibition of protein tyrosine kinases by nuclear-substituted derivatives of 2,2'-dithiobis(1-methyl-N-phenyl-1H-indole-3-carboxamide).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 5.14 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL59812 | — | — | 1 | 6.19 |
| CHEMBL304414 | — | — | 1 | 5.50 |
| CHEMBL64068 | — | — | 1 | 5.46 |
| CHEMBL292323 | — | — | 1 | 5.44 |
| CHEMBL60472 | — | — | 1 | 5.44 |
| CHEMBL293250 | — | — | 1 | 5.41 |
| CHEMBL291979 | — | — | 1 | 5.35 |
| CHEMBL293913 | — | — | 1 | 5.29 |
| CHEMBL62701 | — | — | 1 | 5.28 |
| CHEMBL61278 | — | — | 1 | 5.24 |
| CHEMBL63455 | — | — | 1 | 5.22 |
| CHEMBL64430 | — | — | 1 | 5.14 |
| CHEMBL61119 | — | — | 1 | 5.11 |
| CHEMBL62176 | — | — | 1 | 5.01 |
| CHEMBL291359 | — | — | 1 | 4.96 |
| CHEMBL62699 | — | — | 1 | 4.51 |
| CHEMBL293251 | — | — | 1 | 4.00 |
| CHEMBL64459 | — | — | 1 | 4.00 |
| CHEMBL294341 | — | — | 1 | - |
| CHEMBL64781 | — | — | 1 | - |
| CHEMBL293889 | — | — | 1 | - |
| CHEMBL303127 | — | — | 1 | - |
| CHEMBL291667 | — | — | 1 | - |
| CHEMBL293986 | — | — | 1 | - |
| CHEMBL294205 | — | — | 1 | - |
| CHEMBL64231 | — | — | 1 | - |
| CHEMBL60200 | — | — | 1 | - |
| CHEMBL64165 | — | — | 1 | - |
| CHEMBL64814 | — | — | 1 | - |
| CHEMBL62067 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL59812 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL304414 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL64068 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL292323 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL60472 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL293250 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL291979 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL293913 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL62701 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL61278 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL63455 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL64430 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL61119 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL62176 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL291359 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL62699 | — | IC50 | = | 30700.0 | nM | 4.51 |
| CHEMBL293251 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL64459 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL294341 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL64781 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL293889 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL303127 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL291667 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL293986 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL294205 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL64231 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL60200 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL64165 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL64814 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL62067 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL292287 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL63009 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL62843 | — | IC50 | > | 50000.0 | nM | - |