Assay Detail
Functional
CHEMBL843996
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity determined in the [35S]GTP-gamma-S, binding assay relative to 50 nM U50,488
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
[Pro(3)]Dyn A(1-11)-NH(2): a dynorphin analogue with high selectivity for the kappa opioid receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.51 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL573214 | NORBINALTORPHIMINE | — | 1 | 8.34 |
| CHEMBL407389 | — | — | 1 | 6.42 |
| CHEMBL405097 | — | — | 1 | 6.12 |
| CHEMBL269377 | — | — | 1 | 6.03 |
| CHEMBL413729 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL573214 | NORBINALTORPHIMINE | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL407389 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL405097 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL269377 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL413729 | — | IC50 | = | 2200.0 | nM | 5.66 |