Assay Detail
Functional
CHEMBL844032
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Tested for opioid receptor agonistic activity in guinea pig ileum
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
N-terminal alkylated derivatives of [D-Pro10]dynorphin A-(1-11) are highly selective for kappa-opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.80 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384584 | — | — | 1 | 9.66 |
| CHEMBL425806 | — | — | 1 | 8.67 |
| CHEMBL290543 | — | — | 1 | 8.58 |
| CHEMBL265387 | — | — | 1 | 7.74 |
| CHEMBL413160 | — | — | 1 | 6.16 |
| CHEMBL407529 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384584 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL425806 | — | IC50 | = | 2.16 | nM | 8.67 |
| CHEMBL290543 | — | IC50 | = | 2.61 | nM | 8.58 |
| CHEMBL265387 | — | IC50 | = | 18.3 | nM | 7.74 |
| CHEMBL413160 | — | IC50 | = | 687.0 | nM | 6.16 |
| CHEMBL407529 | — | IC50 | = | 990.0 | nM | 6.00 |