Assay Detail
Binding
CHEMBL844230
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Inhibitory activity against human chymase (h-chymase)
18
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Symmetrical anhydride-type serine protease inhibitors: structure-activity relationship studies of human chymase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.42 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL335675 | — | — | 1 | 8.30 |
| CHEMBL436591 | — | — | 2 | 8.25 |
| CHEMBL424453 | — | — | 1 | 7.89 |
| CHEMBL134821 | — | — | 2 | 7.70 |
| CHEMBL135080 | — | — | 1 | 7.50 |
| CHEMBL134068 | — | — | 1 | 7.43 |
| CHEMBL131704 | — | — | 1 | 7.24 |
| CHEMBL134024 | — | — | 1 | 6.89 |
| CHEMBL108540 | — | — | 1 | 6.57 |
| CHEMBL134268 | — | — | 1 | 5.52 |
| CHEMBL336964 | — | — | 1 | 5.06 |
| CHEMBL134816 | — | — | 1 | 4.89 |
| CHEMBL131794 | — | — | 1 | 4.54 |
| CHEMBL134440 | — | — | 1 | 4.40 |
| CHEMBL338962 | — | — | 1 | 4.33 |
| CHEMBL131747 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL335675 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL436591 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL424453 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL134821 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL135080 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL134068 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL131704 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL134821 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL134024 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL108540 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL436591 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL134268 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL336964 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL134816 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL131794 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL134440 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL338962 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL131747 | — | IC50 | > | 1000000.0 | nM | - |