Assay Detail
Binding
CHEMBL844344
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Tested for [3H]DTG binding to sigma-2 receptor in NG108-15 cell membranes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | NG108-15 |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Expert |
Publication
Evaluation of the effects of the enantiomers of reduced haloperidol, azaperol, and related 4-amino-1-arylbutanols on dopamine and sigma receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.84 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339963 | — | — | 1 | 7.42 |
| CHEMBL340211 | AZAPERONE | 2.0 | 1 | 7.29 |
| CHEMBL60859 | BMY-14802 | — | 1 | 7.02 |
| CHEMBL339033 | — | — | 1 | 6.55 |
| CHEMBL129768 | — | — | 1 | 5.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339963 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL340211 | AZAPERONE | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL60859 | BMY-14802 | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL339033 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL129768 | — | Ki | = | 1235.0 | nM | 5.91 |