Assay Detail
Binding
CHEMBL844554
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Binding affinity for mineralocorticoid receptor
8
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and characterization of non-steroidal ligands for the glucocorticoid receptor: selective quinoline derivatives with prednisolone-equivalent functional activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.05 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL131 | PREDNISOLONE | 4.0 | 1 | 7.43 |
| CHEMBL95644 | — | — | 1 | 6.31 |
| CHEMBL318409 | — | — | 1 | 5.96 |
| CHEMBL99046 | — | — | 2 | 5.77 |
| CHEMBL97206 | — | — | 1 | 5.42 |
| CHEMBL317578 | — | — | 1 | 5.41 |
| CHEMBL419158 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL131 | PREDNISOLONE | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL95644 | — | Ki | = | 493.0 | nM | 6.31 |
| CHEMBL318409 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL99046 | — | Ki | = | 1682.0 | nM | 5.77 |
| CHEMBL97206 | — | Ki | = | 3838.0 | nM | 5.42 |
| CHEMBL317578 | — | Ki | = | 3914.0 | nM | 5.41 |
| CHEMBL419158 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL99046 | — | Ki | > | 5000.0 | nM | - |