Assay Detail
Functional
CHEMBL844735
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In vitro inhibitory activity of compound against microtubule polymerization in a tubulin assembly assay
6
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Total synthesis and anti-tubulin activity of epi-c3 analogues of cryptophycin-24.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.03 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441018 | CRYPTOPHYCIN A | — | 1 | 5.47 |
| CHEMBL123698 | — | — | 1 | 4.97 |
| CHEMBL264224 | ARENASTATIN A | — | 2 | 4.86 |
| CHEMBL124249 | — | — | 1 | - |
| CHEMBL332430 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441018 | CRYPTOPHYCIN A | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL123698 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL264224 | ARENASTATIN A | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL264224 | ARENASTATIN A | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL124249 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL332430 | — | IC50 | > | 100000.0 | nM | - |