Assay Detail
Binding
CHEMBL844884
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Aminoacylation activity against human prolyl-tRNA synthetase
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Bifunctional glutamate/proline--tRNA ligase (CHEMBL3873) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A series of quinoline analogues as potent inhibitors of C. albicans prolyl tRNA synthetase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 4.20 | 4.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL150896 | — | — | 1 | 4.46 |
| CHEMBL149973 | — | — | 1 | 4.25 |
| CHEMBL346646 | — | — | 1 | 4.22 |
| CHEMBL348184 | — | — | 1 | 4.16 |
| CHEMBL150306 | — | — | 1 | 4.10 |
| CHEMBL356452 | — | — | 1 | 4.02 |
| CHEMBL348000 | CINCHOPHEN | 4.0 | 1 | - |
| CHEMBL151890 | — | — | 1 | - |
| CHEMBL150407 | — | — | 1 | - |
| CHEMBL415737 | — | — | 1 | - |
| CHEMBL153295 | — | — | 1 | - |
| CHEMBL357572 | — | — | 1 | - |
| CHEMBL149961 | — | — | 1 | - |
| CHEMBL357355 | — | — | 1 | - |
| CHEMBL153066 | — | — | 1 | - |
| CHEMBL153238 | — | — | 1 | - |
| CHEMBL440534 | — | — | 1 | - |
| CHEMBL345331 | — | — | 1 | - |
| CHEMBL153072 | — | — | 1 | - |
| CHEMBL150266 | — | — | 1 | - |
| CHEMBL150993 | — | — | 1 | - |
| CHEMBL434852 | — | — | 1 | - |
| CHEMBL151039 | — | — | 1 | - |
| CHEMBL153347 | — | — | 1 | - |
| CHEMBL358675 | — | — | 1 | - |
| CHEMBL150924 | — | — | 1 | - |
| CHEMBL345300 | — | — | 1 | - |
| CHEMBL150249 | — | — | 1 | - |
| CHEMBL153564 | — | — | 1 | - |
| CHEMBL150488 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL150896 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL149973 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL346646 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL348184 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL150306 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL356452 | — | IC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL150407 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL151769 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL415737 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL153295 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL357572 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL149961 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL357355 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL153066 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL153238 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL440534 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL345331 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL151890 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL348000 | CINCHOPHEN | IC50 | > | 100000.0 | nM | - |
| CHEMBL153072 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL150266 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL150993 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL434852 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL151039 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL153347 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL358675 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL150924 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL345300 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL150249 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL153564 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL150488 | — | IC50 | > | 20000.0 | nM | - |