Assay Detail
Functional
CHEMBL845009
Review assay metadata, readout intent, target linkage, and publication context from the same page.
pA2 value for the effect in RSV model.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
New selective and potent 5-HT(1B/1D) antagonists: chemistry and pharmacological evaluation of N-piperazinylphenyl biphenylcarboxamides and biphenylsulfonamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 8.49 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL147071 | — | — | 1 | 10.00 |
| CHEMBL15928 | GR-127935 | — | 1 | 9.90 |
| CHEMBL147503 | — | — | 1 | 9.60 |
| CHEMBL146735 | — | — | 1 | 9.10 |
| CHEMBL151420 | — | — | 1 | 8.30 |
| CHEMBL443762 | — | — | 1 | 8.30 |
| CHEMBL359447 | — | — | 1 | 8.00 |
| CHEMBL281350 | SB-224289 | — | 1 | 7.40 |
| CHEMBL422504 | — | — | 1 | 7.30 |
| CHEMBL151894 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL147071 | — | Kd | = | 0.1 | nM | 10.00 |
| CHEMBL15928 | GR-127935 | Kd | = | 0.1259 | nM | 9.90 |
| CHEMBL147503 | — | Kd | = | 0.2512 | nM | 9.60 |
| CHEMBL146735 | — | Kd | = | 0.7943 | nM | 9.10 |
| CHEMBL151420 | — | Kd | = | 5.012 | nM | 8.30 |
| CHEMBL443762 | — | Kd | = | 5.012 | nM | 8.30 |
| CHEMBL359447 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL281350 | SB-224289 | Kd | = | 39.81 | nM | 7.40 |
| CHEMBL422504 | — | Kd | = | 50.12 | nM | 7.30 |
| CHEMBL151894 | — | Kd | = | 100.0 | nM | 7.00 |