Assay Detail
Functional
CHEMBL845118
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Cytotoxicity by the selective inhibition against African green monkey kidney fibroblast (vero cells).
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Chlorocebus sabaeus |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Development of 2,4-diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine-resistant Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.74 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278813 | — | — | 1 | 5.52 |
| CHEMBL278847 | — | — | 1 | 5.16 |
| CHEMBL22139 | — | — | 1 | 4.89 |
| CHEMBL22403 | — | — | 1 | 4.82 |
| CHEMBL22901 | — | — | 1 | 4.47 |
| CHEMBL25112 | — | — | 1 | 4.35 |
| CHEMBL21885 | — | — | 1 | 4.00 |
| CHEMBL22327 | — | — | 1 | - |
| CHEMBL416373 | — | — | 1 | - |
| CHEMBL22693 | — | — | 1 | - |
| CHEMBL21395 | — | — | 1 | - |
| CHEMBL22148 | — | — | 1 | - |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278813 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL278847 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL22139 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL22403 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL22901 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL25112 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL21885 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL22327 | — | IC50 | = | 200000.0 | nM | - |
| CHEMBL416373 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL22693 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL21395 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL22148 | — | IC50 | = | 320000.0 | nM | - |
| CHEMBL22 | TRIMETHOPRIM | IC50 | > | 50000.0 | nM | - |