Assay Detail
Functional
CHEMBL845182
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of progression of cells from G1 into S-phase by BrdU incorporation assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.67 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL409892 | GW305178X | — | 1 | 6.54 |
| CHEMBL1964245 | — | — | 1 | 6.19 |
| CHEMBL271136 | — | — | 1 | 5.96 |
| CHEMBL391229 | — | — | 1 | 5.82 |
| CHEMBL411426 | — | — | 1 | 5.75 |
| CHEMBL269883 | GW416981X | — | 1 | 5.64 |
| CHEMBL1276446 | — | — | 1 | 5.58 |
| CHEMBL1964244 | — | — | 1 | 5.48 |
| CHEMBL1964250 | — | — | 1 | 5.27 |
| CHEMBL1964242 | — | — | 1 | 5.11 |
| CHEMBL1964260 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL409892 | GW305178X | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1964245 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL271136 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL391229 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL411426 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL269883 | GW416981X | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1276446 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1964244 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1964250 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL1964242 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL1964260 | — | IC50 | = | 8300.0 | nM | 5.08 |