Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL845189

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of TNF-alpha-induced VCAM-1 expression
ChEMBL ↗
79
Total Activities
79
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Tumor necrosis factor receptor superfamily member 1A (CHEMBL3378) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of novel heteroaryl-substituted chalcones as inhibitors of TNF-alpha-induced VCAM-1 expression.
Meng CQ, Zheng XS, Ni L, Ye Z, Simpson JE, Worsencroft KJ, Hotema MR, Weingarten MD, Skudlarek JW, Gilmore JM, Hoong LK, Hill RR, Marino EM, Suen KL, Kunsch C, Wasserman MA, Sikorski JA.
Bioorg Med Chem Lett (2004) 14 : 1513 -1517
PubMed 15006393 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 79 5.41 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL290167 — — 1 6.00
CHEMBL39798 — — 1 6.00
CHEMBL39896 — — 1 6.00
CHEMBL289427 — — 1 6.00
CHEMBL37662 — — 1 6.00
CHEMBL37663 — — 1 6.00
CHEMBL39656 — — 1 6.00
CHEMBL263418 — — 1 6.00
CHEMBL39400 — — 1 5.70
CHEMBL37200 — — 1 5.70
CHEMBL449083 — — 1 5.70
CHEMBL290392 — — 1 5.70
CHEMBL36371 — — 1 5.70
CHEMBL435172 — — 1 5.70
CHEMBL35981 — — 1 5.70
CHEMBL285544 — — 1 5.70
CHEMBL405035 — — 1 5.70
CHEMBL36742 — — 1 5.70
CHEMBL37382 — — 1 5.70
CHEMBL38233 — — 1 5.70
CHEMBL36771 — — 1 5.70
CHEMBL40731 — — 1 5.70
CHEMBL38312 — — 1 5.70
CHEMBL40330 — — 1 5.52
CHEMBL287939 — — 1 5.52
CHEMBL39783 — — 1 5.52
CHEMBL40331 — — 1 5.52
CHEMBL37120 — — 1 5.52
CHEMBL39549 — — 1 5.52
CHEMBL37677 — — 1 5.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL290167 — IC50 = 1000.0 nM 6.00
CHEMBL39798 — IC50 = 1000.0 nM 6.00
CHEMBL39896 — IC50 = 1000.0 nM 6.00
CHEMBL289427 — IC50 = 1000.0 nM 6.00
CHEMBL37662 — IC50 = 1000.0 nM 6.00
CHEMBL37663 — IC50 = 1000.0 nM 6.00
CHEMBL39656 — IC50 = 1000.0 nM 6.00
CHEMBL263418 — IC50 = 1000.0 nM 6.00
CHEMBL39400 — IC50 = 2000.0 nM 5.70
CHEMBL37200 — IC50 = 2000.0 nM 5.70
CHEMBL449083 — IC50 = 2000.0 nM 5.70
CHEMBL290392 — IC50 = 2000.0 nM 5.70
CHEMBL36371 — IC50 = 2000.0 nM 5.70
CHEMBL435172 — IC50 = 2000.0 nM 5.70
CHEMBL35981 — IC50 = 2000.0 nM 5.70
CHEMBL285544 — IC50 = 2000.0 nM 5.70
CHEMBL405035 — IC50 = 2000.0 nM 5.70
CHEMBL36742 — IC50 = 2000.0 nM 5.70
CHEMBL37382 — IC50 = 2000.0 nM 5.70
CHEMBL38233 — IC50 = 2000.0 nM 5.70
CHEMBL36771 — IC50 = 2000.0 nM 5.70
CHEMBL40731 — IC50 = 2000.0 nM 5.70
CHEMBL38312 — IC50 = 2000.0 nM 5.70
CHEMBL39783 — IC50 = 3000.0 nM 5.52
CHEMBL35697 — IC50 = 3000.0 nM 5.52
CHEMBL261943 — IC50 = 3000.0 nM 5.52
CHEMBL34980 — IC50 = 3000.0 nM 5.52
CHEMBL435770 — IC50 = 3000.0 nM 5.52
CHEMBL37331 — IC50 = 3000.0 nM 5.52
CHEMBL40003 — IC50 = 3000.0 nM 5.52
CHEMBL416424 — IC50 = 3000.0 nM 5.52
CHEMBL37677 — IC50 = 3000.0 nM 5.52
CHEMBL39549 — IC50 = 3000.0 nM 5.52
CHEMBL37120 — IC50 = 3000.0 nM 5.52
CHEMBL40331 — IC50 = 3000.0 nM 5.52
CHEMBL287939 — IC50 = 3000.0 nM 5.52
CHEMBL40330 — IC50 = 3000.0 nM 5.52
CHEMBL279582 — IC50 = 3000.0 nM 5.52
CHEMBL39624 — IC50 = 4000.0 nM 5.40
CHEMBL290710 — IC50 = 4000.0 nM 5.40
CHEMBL39558 — IC50 = 4000.0 nM 5.40
CHEMBL36155 — IC50 = 4000.0 nM 5.40
CHEMBL39751 — IC50 = 4000.0 nM 5.40
CHEMBL284503 — IC50 = 4000.0 nM 5.40
CHEMBL39895 — IC50 = 4000.0 nM 5.40
CHEMBL35999 — IC50 = 4000.0 nM 5.40
CHEMBL288650 — IC50 = 4000.0 nM 5.40
CHEMBL33897 — IC50 = 4000.0 nM 5.40
CHEMBL36829 — IC50 = 5000.0 nM 5.30
CHEMBL39359 — IC50 = 5000.0 nM 5.30