Assay Detail
Functional
CHEMBL845252
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tubulin (10 uM) polymerization, after a 20 min incubation at 30 degrees Centigrade
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Bos taurus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
One-pot synthesis of benzo[b]furan and indole inhibitors of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.66 | 6.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90904 | — | — | 1 | 6.39 |
| CHEMBL409088 | — | — | 1 | 5.89 |
| CHEMBL89341 | — | — | 1 | 5.80 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.68 |
| CHEMBL314534 | — | — | 1 | 5.60 |
| CHEMBL310038 | — | — | 1 | 5.47 |
| CHEMBL327414 | — | — | 1 | 5.39 |
| CHEMBL90441 | — | — | 1 | 5.06 |
| CHEMBL90926 | — | — | 1 | - |
| CHEMBL273425 | — | — | 1 | - |
| CHEMBL89039 | — | — | 1 | - |
| CHEMBL327181 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90904 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL409088 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL89341 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL314534 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL310038 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL327414 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL90441 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL90926 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL273425 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL89039 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL327181 | — | IC50 | > | 40000.0 | nM | - |