Assay Detail
Functional
CHEMBL845404
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration was determined from in vitro cellular peroxide toxicity assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and synthesis of poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors. Part 3: In vitro evaluation of 1,3,4,5-tetrahydro-benzo[c][1,6]- and [c][1,7]-naphthyridin-6-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 6.57 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL84096 | — | — | 1 | 7.52 |
| CHEMBL444846 | — | — | 1 | 7.40 |
| CHEMBL84979 | — | — | 1 | 7.40 |
| CHEMBL83224 | — | — | 1 | 7.35 |
| CHEMBL84741 | — | — | 1 | 7.24 |
| CHEMBL84192 | — | — | 1 | 7.22 |
| CHEMBL310320 | — | — | 1 | 7.00 |
| CHEMBL84886 | — | — | 1 | 6.58 |
| CHEMBL84371 | — | — | 1 | 6.21 |
| CHEMBL312316 | — | — | 1 | 6.16 |
| CHEMBL85733 | — | — | 1 | 6.07 |
| CHEMBL83432 | — | — | 1 | 5.75 |
| CHEMBL313782 | — | — | 1 | 5.55 |
| CHEMBL310120 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL84096 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL444846 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL84979 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL83224 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL84741 | — | EC50 | = | 58.0 | nM | 7.24 |
| CHEMBL84192 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL310320 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL84886 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL84371 | — | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL312316 | — | EC50 | = | 690.0 | nM | 6.16 |
| CHEMBL85733 | — | EC50 | = | 850.0 | nM | 6.07 |
| CHEMBL83432 | — | EC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL313782 | — | EC50 | = | 2790.0 | nM | 5.55 |
| CHEMBL310120 | — | EC50 | = | 30000.0 | nM | 4.52 |