Assay Detail
Functional
CHEMBL845437
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Tested for the NMDA antagonist activity, glutamate induced LDH release in cultured neuronal cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | neuronal |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and anticonvulsant activity of the (+)- and ()-enantiomers of 1,2,3,4-tetrahydro-5-(2-phosphonoethyl)-3-isoquinolinecarboxylic acid, a competitive NMDA antagonist
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.06 | 5.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2115546 | — | — | 1 | 5.06 |
| CHEMBL22304 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2115546 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL22304 | — | IC50 | = | 9000.0 | nM | 5.05 |