Assay Detail
Binding
CHEMBL846060
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Concentration required for 50% in vitro activity against rat SDH (sorbitol dehydrogenase)
10
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A sorbitol dehydrogenase inhibitor of exceptional in vivo potency with a long duration of action: 1-(R)-[4-[4-(4,6-dimethyl[1,3,5]triazin-2-yl)- 2R,6S-dimethylpiperazin-1-yl]pyrimidin-2- yl]ethanol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.00 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL136680 | — | — | 2 | 8.40 |
| CHEMBL342697 | — | — | 1 | 8.30 |
| CHEMBL136900 | — | — | 1 | 8.22 |
| CHEMBL136420 | — | — | 1 | 8.15 |
| CHEMBL136103 | — | — | 1 | 8.00 |
| CHEMBL287890 | — | — | 1 | 7.96 |
| CHEMBL435428 | — | — | 1 | 7.96 |
| CHEMBL2111939 | — | — | 1 | 7.50 |
| CHEMBL139187 | — | — | 1 | 7.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL136680 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL342697 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL136900 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL136420 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL136680 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL136103 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL287890 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL435428 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2111939 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL139187 | — | IC50 | = | 39.0 | nM | 7.41 |